Effects of the treatment of Thymosin alpha1 on the immune function of patients with drug-resistant pulmona-ry tuberculosis

doi:10.3969/j.issn.1674-3806.2015.06.17

Abstract：Objective To observe the clinical effects of the treatment of Thymosin alpha1 on drug resistant pulmonary tuberculosis, and its effects on the patients′immune function( Th17/Treg) .Methods Sixty-four patients with drug-resistant pulmonary tuberculosis were randomly divided into the observation group and the treatment group (32 cases in each group).The two groups were treated with western medicine of anti-tuberculosis drug for 18 months as a treatment course.Intramuscular injection of Thymosin alpha1 was added to the treatment group 1.6 mg per time, 2 times a week, consecutively for 3 months.30 healthy people were taken as the control group.The improvement of tuberculosis lesions, sputum negative conversion rate, peripheral blood T lymphocyte expression and the efficiency and drug adverse reactions were compared between the two groups before and after the treatment.Results ( 1 ) The total efficiency of the observation group and the treatment group were 56.7%and 83.3%( P<0.05 ) .( 2 ) The im-provement of tuberculosis lesions and sputum negative rate of the treatment group were higher than those of the obser-vation group after 3 and 6 months of the treatment.(3) Th17, Treg and Th17/Treg in the peripheral blood of the two groups were decreased significantly compared with the control group(P<0.01).Th17, Treg and Th17/Treg in the peripheral blood of the treatment group were increased significantly after 3 and 6 the months of the treatment compared with those before the treatment(P<0.01).There was significant difference between the two groups(P<0.05).(4) The incidences of adverse reaction of the observation group and the treatment group were 26.6% and 20%( P>0.05 ) .Conclusion Thymosin alpha1 can increase the patients′immune function and improve the X-ray and clinical efficacy in treatment of drug resistant tuberculosis.