Studies on the related factors of poor virological response to the ADV treatment of chronic hepatitis B

ZHAO Hong-kui; BIAN Cheng

doi:10.3969/j.issn.1674-3806.2015.06.12

Abstract：Objective To investigate the factors of poor virological response to adforvir dipivoxil(ADV) treatment in patients with chronic hepatitis B.Methods The clinical data of the factors of poor virological response to ADV treatment in patients with chronic hepatitis B were retrospectively analyzed from January 2011 to January 2014. Results BMI, HBV DNA, HBsAg when HBeAg was positive and BMI, HBV DNA when HBeAg was negative were correlated with the response(P<0.05).There was significantly difference in V of 181 mutations (≥5%) and T of 236 mutations (≥5%) when HBeAg was positive ( P<0.05) .There was significantly difference in T of 236 muta-tions (≥5%) when HBeAg was negative(P<0.05).But there were no significant differences in V of 181 mutations (<5%) when HBeAg was negative ( P>0.05 ) .HBV DNA which was lower than the basic levels in 12 and 24 weeks after treatment (1.326 ±0.907)log10copies/ml and (1.279 ±1.156)log10copies/ml was easy to have the poor virological response(P<0.05) in the HBeAg positive patients.HBV DNA which was lower than the basic levels in 12 and 24 weeks after treatment (0.983 ±0.706) log10copies/ml and (1.178 ±0.736) log10copies/ml was easy to have the poor virological response( P<0.05) in the HBeAg negative patients.There were no obvious relationships between the changes of ALT and AST and the response(P>0.05).Conclusion The baseline data and the changes of HBV DNA are the factors of poor virological response to ADV treatment in patients with chronic hepatitis B.Individual-ized treatments should be established according to the above data to reduce the incidence of poor response phenomenon.