Analysis of pathogen distributions and antibiotic resistances in neonatal blood cultures

doi:10.3969/j.issn.1674-3806.2015.05.16

Abstract：Objective To investigate pathogen distribution and antibiotic resistance characteristics in neo-natal blood cultures and provide a scientific basis for the treatment of neonatal septicemia and the rational use of anti-biotics.Methods The clinical data of neonatal blood cultures were statistically analyzed retrospectively from January 2014 to December 2014.Results The positive rate of blood cultures was 6.2%(280/4512).Gram-positive coccus were the predominant, accounting for 71.9%( 212/295 ) , among which coagulase negative staphylococcus ( CNS ) were 59.0%(174/295);Gram-negative bacteria, accounted for 23.4%(69/295), other pathogens 14 strains, ac-counted for 4.7%(14/295).The resistant rates of CNS to penicillin, tetracycline, gentamicin and oxacillin were be-tween 60.0%and 100.0%.The resistant rates of CNS to vancomycin, teicoplanin, fusidicacid, nitrofurantoin, and minocycline were low, ranging from 0.0%to 15.8%.The resistant rates of Klebsiella pneumoniae and Escherichia coli to cephalothin, cefuroxime and amoxicillin were between 79.5%and 97.4%.Conclusion CNS are the predom-inant pathogens in the neonatal blood cultures and the resistance rates of CNS and some Gram-negative bacilli to some frequently-used antibacterials are high.It is necessary to take measures to monitor the drug resistance of strains and use antibacterials reasonably.