Effect of large dose of ulinastatin on respiratory mechanics and oxidative stress in patients with acute respira-tory distress syndrome
LI Jing
YANG Yu-ling
YUAN Dong-dong
Abstract：Objective To investigate the effect of large dose of ulinastatin on respiratory mechanics and oxi-dative stress in patients with acute respiratory distress syndrome(ARDS).Methods 54 patients with ARDS in our hospital from Jan.2011 to Aug.2013 were randomly divided into observation group and control group, with 27 cases in each group.The control group was treated with conventional therapy.The observation group was treated with large dose of ulinastatin on basis of conventional treatment, the changes of respiratory mechanics indexes and oxidative stress parameters before and after treatment between the two groups were compared.Results The positive end expira-tory pressure( PEEP) in the control group was significantly lower than that before treatment, the static lung compli-ance was significantly higher than that before treatment(P<0.05);the inspiratory resistance and PEEP in the obser-vation group were significantly lower than those before treatment(P<0.05), the static lung compliance was signifi-cantly higher than that before treatment(P<0.05).After treatment, the inspiratory resistance and PEEP in the ob-servation group were significantly lower than those in the control group(P<0.05), the static lung compliance was significantly higher than that in the control group(P<0.05).Malondialdehyde in the control group was significantly lower than that before treatment(P<0.05), superoxide dismutase was significantly higher than that before treatment (P<0.05);malondialdehyde in the observation group was significantly lower than that before treatment(P<0.05), superoxide dismutase, glutathione and total oxidative capacity were significantly higher than those before treatment ( P<0.05).After treatment, malondialdehyde in the observation group was significantly lower than that in the control group, superoxide dismutase, glutathione and total oxidative capacity were significantly higher than those in the con-trol group( all P<0.05) .Conclusion Large dose of ulinastatin intravenous injection can effectively improve respira-tory mechanics and oxidative stress of patients with ARDS, reduce lung injury, improve pulmonary ventilation func-tion and play a positive role in improving prognosis of patients with ARDS.
Keywords：UlinastatinAcute respiratory distress syndrome( ARDS)Respiratory mechanicsOxida-tive stress
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 437-440 )