The efficacy and safety research of large dose LMWH with urokinase sequential therapy for intracranial ve-nous sinus thrombosis

doi:10.3969/j.issn.1674-3806.2015.05.13

Abstract：Objective To study the efficacy and safety of large dose LMWH with urokinase sequential thera-py for intracranial venous sinus thrombosis.Methods Ninety-seven patients with intracranial venous sinus thrombosis were selected, according to different anticoagulation therapies and divided into 3 groups, experimental A group ( 33 cases), using large dose of LMWH(5 000 U, twice/d) with urokinase(100 000 U, once/d) sequential therapy, ex-perimental B group(32 cases), using low dose of LMWH(5 000 U, once/d) with urokinase(100 000 U, once/d) sequential therapy, control group(32 cases), using warfarin 2.5 mg, qd, P.O.Therapeutic effects and adverse re-actions in all groups were compared.Results The efficient rate and sinus revascularization rate of experimental A group were the highest.Followed were respectively experimental B group and the control group(P<0.05).Before the treatment, there was no significant difference in the average intracranial pressure among the three groups ( P>0.05).After 3 or 6 months′treatment, the average intracranial pressure of experimental A or B group was obviously lower than that of the control group and pre-therapy(P<0.05).There was significant difference between the experi-mental A and B group ( P<0.05 ) .The highest recovery rate and the lowest mortality rate were in experimental A group.Followed was experimental B group.The lowest recovery rate and the highest mortality rate were in the control group( P<0.05 ) .There was no significant difference in the extracranial blood rate among the three groups ( P>0.05).After symptomatic treatment all were relieved.Conclusion A large dose of LMWH with urokinase sequential therapy is efficient for intracranial venous sinus thrombosis.It can enhance thrombosis absorption, increase venous si-nus revascularization, reduce intracranial pressure and improve prognosis.