Application comparative study of dexmedetomidine and propofol for patients undergoing mechanical ventila-tion after cardiac surgery

doi:10.3969/j.issn.1674-3806.2015.05.10

Abstract：Objective To compare the sedative effect and safety of dexmedetomidine and propofol for pa-tients undergoing mechanical ventilation after cardiac surgery.Methods A total of 70 patients undergoing mechanical ventilation after cardiac surgery in the intensive care unit( ICU) were enrolled.They were treated either with propofol (35 cases in propofol group) or dexmedetomidine(35 cases in dexmedetomidine group).The dose of sedation was regulated by Riker sedation-agitation scale( SAS) maintaining 3~4 sedative score.During the course, the amount of the sufentanil, duration of mechanical ventilation, using time of vasoactive agent, SAS score, extubation time,and in-cidence of side-effects such as hypotension, bradycardia, delirium or agitation, etc were recorded in the two groups. Results There was no statistically significant difference in the sedative effect between the two groups.Riker SAS score was maintained in 3~4 sedative scores(P>0.05).When compared with the propofol group, in the dexme-detomidine group, the dose of sufentanil was smaller(P<0.01), extubation time was shorter(P<0.01), the rates of hypotension and bradycardia were the same( P>0.05) ,and the duration of mechanical ventilation, using time of vasoactive agent, SAS score were the same(P>0.05).The rate of delirium or agitation in the dexmedetomidine was lower than that in the propofol group(14.3%vs 40.0%, P<0.05).Conclusion Sedative effect of dexmedetomi-dine is satisfactory and effective for patients undergoing mechanical ventilation after cardiac surgery.It can reduce the rate of delirium or agitation.