Effect of methylprednisolone on the levels of CD80 and CD86 in mice with experimental autoimmune enceph-alomyelitis
Abstract：Objective To explore the effect of methylprednisolone on the levels of cluster of differentiation (CD)80 and CD86 in the central nervous system of mice with experimental autoimmune encephalomyelitis(EAE). Methods The EAE model was induced in mice by immunized with myelin oligodendrocyte glycoprotein peptides (MOG35-55).30 female C57BL/6J mice were randomly divided into 3 groups: methylprednisolone-treated group, EAE group and normal group.The brain tissues were collected and their expressions of CD80 and CD86 were detected using western blot.Results The neurological deficits of the methylprednisolone-treated mice were lighter than those of the EAE mice(P<0.05), while the methylprednisolone-treated mice displayed the lower expression of CD80 and the higher expression of CD86 than the EAE mice did(P<0.05).Conclusion Methylprednisolone can protect a-gainst EAE in mice by the inhibition of CD80 and upregulation of CD86.
Keywords：MethylprednisoloneExperimental autoimmune encephalomyelitis(EAE)Multiple sclero-sisCD80CD86
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 416-418 )