The changes of plasma L-carnitine levels in patients with multiple myeloma and their clinical significances
Abstract：[ Abstarct] Objecti ev To investigate the changes of plasma L-carnitine levels in the patients with multiple myeloma( MM) before and after the chemotherapy and explore their clinical significances .Mtehods The levels of plasma L-carnitine of 10 healthy people and 36 MM patients ( 21 initially-diagnosed and 15 relapsed patients with MM) were tested.All patients were given chemotherapy with or without anthracyclines and the levels of plasma L-carnitine were tested by high performance liquid chromatography.Results The levels of plasma L-carnitine of initial-ly-diagnosed and relapse patients with MM were lower than those of healthy people, but the levels of relapsed MM were lower than those initially-diagnosed MM(P<0.05);Those levels of plasma L-carnitine of MM one day and one week after chemotherapy were lower than those before chemotherapy.Chemotherapy with anthracyclines can reduce the levels of plasma L-carnitine of MM patients ( P<0.05 ) .Conclusion Chemotherapy could ruduce the levels of plasma L-carnitine of MM patients,indicating that it could be important to supplement L -carnitine during the chemo-therapy.
Keywords：Multiple myeloma( MM)L-carnitine
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 410-412 )