Effects of dexmedetomidine combined with ketamine on postoperative cognitive dysfunction in elderly patients with burns
Abstract：Objective To study the effects of dexmedetomidine combined with ketamine on postoperative cognitive dysfunction in elderly patients with burns .Methods Sixty cases of the elderly patients with burns were ad-ministered anesthetic ketamine (group K, n=30) and the other cases were administered anesthetic dexmedetomidine combinedation with ketamine (group DK, n=30).The postoperative cognitive dysfunctions in the groups were ob-served respectively on the first , the third and the seventh day after operation .Results Scores of MMSE in the two groups were both decreased compared with pre-operation(P<0.05).On the third and seventh day the scores in the two groups were increased than those on the first day in some extent , but they were both significantly lower than those before operation ( P<0.05 ) .The score of group K was significantly decreased compared with group DK ( P<0.05 ) . The percentages of POCD in both group K and group DK had no significant difference ( P>0.05 ) .Conclusion Dexmedetomidine combined with ketamine in anesthesia improves postoperative cognitive dysfunction in elderly pa -tients with burns compared with using ketamine alone .It has no effect on the occurrence of POCD .
Keywords：Key words] DexmedetomidineKetamineElderly patientsBurnPostoperative cognitive dysfunc-tion( POCD)Mini-mental state examination ( MMSE)
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 321-323 )