Clinical efficacy of molecular weight heparin in the treatment of unexplained early recurrent spontaneous a-bortion
LIANG Qing-fen
Abstract：Objective To investigate the clinical effect and safety of low molecular weight heparin ( LMWH) for unexplained early recurrent spontaneous abortion ( RSA) .Methods One hundred patients with unexplained RSA were randomly divided into treatment group and control group , with 50 cases in each group .Both groups began to re-ceive drugs treatment from early pregnancy , usually after pregrancy was diagnosed by the blood β-HCG or intrauterine pregnancy was dinenosed by ultrasound examination .The control group received the following therapy: progesterone 20 mg, intramuscular injection , once a day;chorionic gonadotropin 1 000 U, intramuscular injection , once a day un-til 12 weeks of pregnancy .The treatment group was given low molecular weight heparin 5 000 U pariumbilical subcu-taneous injection once a day based on the above treatment .After treatment, the pregnancy outcomes , drug side effects and neonatal malformations were observed in the two groups .Results The live births rate in the treatment group was 90%, that in the control group was 62%, the difference in the live births rate between the two groups was statistically significant ( P <0.05 ); the incidence of adverse drug reactions in the control group was 74%, higher than that ( 24%) in the treatment group , the difference was statistically significant ( P<0.05 );there were no neonatal malfor-mations in the two groups .Conclusion LMWH can significantly improve the pregnancy outcome of patients with un-explained early recurrent spontaneous abortion and has no adverse effects on the newborns .
Keywords：Early recurrent sponeous abortionLow molecular weight heparin ( LMWH)Clinical effect
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 312-314 )