Combined application of micro-gel method and glycine/EDTA diffuse method in the detection of hemolytic disease of the newborn:report of 277 cases
Abstract：Objective To explore the clinical value of combined application of micro-gel method and gly-cine/EDTA diffuse method in the diagnosis of hemolytic disease of the newborn ( HDN) caused by maternal-fetal blood type incompatibility .Methods Micro-gel method and glycine/EDTA diffuse method were jointly used to detect 355 blood samples from newborn with suspected HDN caused by maternal-fetal blood type incompatibility .Results HDN caused by maternal-fetal blood type incompatibility was diagnosed in 277 cases, the positive rate was 78.03%, of which Rh-HDN was detected in 2 cases(0.72%), ABO-HDN in 275 cases(99.28%).In 275 cases of ABO-HDN, mother and baby were both blood type O/A accounted for 48.73%, O/B accounted for 51.27%, no B/AB and A/AB blood type.For these newborn with jaundice between 2 h≤n≤3 d,3 d<n≤5 d,5 d<n≤7 d,7 d<n≤13 d after birth.HDN positive detection rates were 86.10%, 73.02%, 31.58%, 14.29%, respectively.Conclusion Joint application of micro-gel method and glycine /EDTA diffuse method in the detection of HDN , can accurately and timely provide the basis for clinical diagnosis and treatment .
Keywords：Maternal-fetal blood type incompatibilityHemolytic disease of the newbornMicro-gel methodGlycine/EDTA diffuse methodHyperbilirubinemia
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 308-311 )