Effects of early administration of large dose rosuvastatin on coronary microvascular function and short-term outcome in patients treated with primary PCI for acute myocardial infarction
FAN Fu-rong
HOU Yan
Abstract：Objective To investigate the effects of early administration of large dose rosuvastatin (40 mg) on coronary microvascular function and short-term outcome in patients treated with primary percutaneous coronary inter-vention for acute myocardial infarction .Methods 94 consequent AMI patients treated with primary PCI were divided into control group ( n=44 ) and observation group ( n=50 ) .The infarct-related artery flow of epicardium was classi-fied in compliance with the TIMI criteria .Myocardial and microvascular perfusion was assessed using the TMPG .The incidence of the MACE and the cytotoxicity and hepatotoxicity of rosuvastatin were respectively recorded in 30 days′follow-up.Results TMPG in both observation group and control group improved immediately after PCI ( P<0.05 ) . However , the post-PCI TMPG of observation group improved better than that of the control group ( P<0.05 ) .The 30-day composite MACE rate was lower in the observation group than that in the control group (12.0% vs 34.1%,P<0.05 ) .The incidence of TMPG 3 patients was lower in observation group than that in the control group ( 11.1% vs 42.9%,P<0.05).No cytotoxicity and hepatotoxicity happened in the two groups .Conclusion Early administration of large dose rosuvastatin(40 mg) can improve coronary microvascular function and short-term outcome in patients treated with primary percutaneous coronary intervention for acute myocardial infarction , and is safe .
Keywords：Myocardial infarctionVascular interventionRosuvastatinPrognosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 241-244 )