Effects of different doses of olanzapine on blood glucose and lipids in male schizophrenic patients

ZHANG Dong-wei

doi:10.3969/j.issn.1674-3806.2015.03.10

Abstract：Objective To explore the effects of different doses of olanzapine treatment on blood glucose and lipids in male schizophrenics .Methods Sixty male schizophrenic patients were divided into two groups randomly and olanzapine were given at 5~15 mg per day(low dose group) and 16~25 mg per day(high dose group).Weight, blood glucose and lipids were measured before treatment and after 28 days′treatment meanwhile PANSS was used to assess the psychological symptoms .Results Weight gains in the two groups were significant after treatment ( t =11.326 , 14.355 ) and there were significant differences ( P<0.01 ) .There was no significant difference in weight gains between groups after treatment .The serum levels of total cholesterol ( TCH) and triglyceride ( TG) in the two groups after treatment were increased than those before treatment and there were significant differences ( P<0.01 ) , but there was no significant difference between two groups after treatment .Compared before treatment , there was no significant difference in the levels of glucose and high density lipoprotein-cholesterol ( HDL) in the two groups after treatment and there was no significant difference between the two groups ( P>0.05 ) .Compared before treatment , the total scores of PANSS in the two groups were decreased after treatment and there were significant differences ( P<0.01 ) , but there was no significant difference between two groups after treatment .Conclusion Olanzapine can in-crease weight and the level of lipid in male schizoprenic patients and it may not be related with treatment dose .