Experimental study on the treatment of bone nonunion of rabbit radius by extracorporeal shock wave com-bined with hyperbaric oxygen

doi:10.3969/j.issn.1674-3806.2015.03.05

Abstract：Objective To explore the effect and action mechanism of extracorpoporeal shock wave combined with hyperbaric oxygen in the treatment of bone ununion .Methods Forty-eight health standard experiment New Zeal-and white rabbits were chosen ( months of age are consistent with weights ) , and divided into four groups by using the random number table after the models were made by osteotomy (12 in each group).The group A was extracorporeal shock wave combined with hyperbaric oxygen group; The group B was hyperbaric oxygen group; The group C was pure extracorporeal shock wave group;The group D was in control group , X-ray examination was made before treat-ment and at 2, 4, 8, 12 weeks after treatment;and part of the experimental animals were executed at each time point to get the live tissue for making general observation , observing the change of nonunion gap , detecting the calcium content, using the optical microscope to observe the osteoblast in bone callus , and statistical analysis of the data was made at last.Results X-ray obseversion showed that there was a significant difference in the nonunion gap at 4, 8, 12 weeks between group A and group B , C or D(P<0.05).Callus calcium contents at 2, 4, 8, 12 weeks in group A were higher than those in group C , the difference was statistically significant ( P<0.05 ) .There was a significant difference in callus osteoblast count at 2, 4, 8 weeks between group A and group C (P<0.05).Conclusion Extra-corporeal shock wave combined with hyperbaric oxygen treatment for bone nonunion is better than pure extracorporeal shock wave therapy , simple hyperbaric therapy has no obvious help for the treatment of bone nonunion , hyperbaric oxygen can be used as a good synergy method in the extracorporeal shock wave treatment of bone nonunion .