Expression a nd significance of MMP-3 in prominent intervertebral disc tsisue and blood in rat model of inter-vertebral disc herniati on
QIN Jin-ding
JIANG Yao-chuan
XIAO Rong-chi
Abstract：Objective To detect the change of MMP-3 in the prominent intervertebral disc tissue and blood in rats of intervertebral disc herniation to explore the feasibility of conservative treatment for intervertebral disc hernia -tion with MMP3-.Methods Forty SD rats(only 3 months of age) were randomly divided into normal control group , negative control group,experimental group 1 and experimental group 2, 10 in each group.The MMP-3 content in disc herniation organization and the blood were detected with enzyme -linked immunosorbent assay method after 45 days of experiment.Re sults (1)The expression of MMP-3 was significantly higher in the experimental group 1 and group 2 compared with that of normal control group (P<0.05);(2)The express of MMP-3 was significantly higher in group 1 compared with that of group 2(P<0.05); (3)the concentration of MMP-3 between intervertebral disc tissue and blood in group 1 and group 2, had a linearly relating, and the correlation coefficients were 0.835, and 0.924 ( P<0.05 ) .Conclusion The content of MMP-3 in the blood rises in the process of intervertebral disc hernia -tion resorption ,and content of MMP-3 in local intervertebral disc tissue is highly correlated with the level of that in the blood, idea of nonsurgical treatment by local injections with MMP-3 to cure intervertebral disc herniation may not come true in the clinical use .
Keywords：Intervertebral disc erniationResorptionMMP-3Enzyme-linked immunosorbent assay
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 205-209 )