Experimental study on the treatment of bone nonunion of rabbit radius by extracorporeal shock wave com-bine veronica peregrina L

doi:10.3969/j.issn.1674-3806.2015.03.03

Abstract：Objective To explore the action mechanism of extracorporeal shock wave combined with Chinese herbal medicine ( veronica peregina L ) in the treatment on rabbit bone nonunion .Methods Sixty-four standard ex-periment New Zealand white rabbits were chosen , the rabbit models of radial bone nonunion were made under aseptic conditions by osteotomy , then randomly divided into A , B, C, D group.Group A was treated by extracorporeal shock wave combined with Chinese herbal medicine ( veronica peregina L );Group B was treated by bone Veronica peregrina L;Group C was treated by extracorporeal shock wave; Group D was control. The generation of bone callus of each group before and after the treatment were observe and compared , and statistical analysis was performed .Results The generation of bone callus:the comparision among groups of the bone callus after the treatment at each time point the difference was statisticlly significant(P<0.01);In group A, the generation of bone callus after the treatment by ex-tracorporeal shock wave was higher than group C at 2, 4, 6, 8 weeks, the difference was statistically significant (P<0.01 );Group A was higher than group D in the generation of bone callus , the difference was statistically significant ( P<0.01 );The generation of bone callus at each time point between goup B and group D did not show significant difference ( P>0.05 ) .Conclusion Veronica peregrina L can accelerate fracture healing after bone nonunion treated by extracorporeal shock wave in the early time that provides a good method for the non -surgical treatment of bone non-union.