Relationship between hsCRP, serum lipid level and left ventricular hypertrophy in patients with hypertension
GUAN Wei
Abstract：Objective To investigate the relationship between hsCRP, serum lipid level and left ventricular hypertrophy( LVH) in patients with hypertension.Methods Eighty-two patients with hypertension and 76 controls were included, hsCRP,FPG, TC, TG,HDL-C and LDL-C were measured.All subjects were taken echocardiography examination, then LVMI was calculated.Results (1)hsCRP, LVMI and TG in patients with hypertension were sig-nificantly higher than those in controls[(5.13 ±2.36)mg/L vs (4.06 ±2.21)mg/L,P=0.006;(108.7 ±9.9)g/m2 vs (88.3 ±10.4)g/m2,P=0.000;(3.0 ±0.6)mmol/L vs (1.3 ±0.5)mmol/L,P=0.000],and HDL-C in pa-tients with hypertension was significantly lower than that in controls[(1.0 ±0.1)mmol/L vs (1.6 ±0.1)mmol/L,P=0.004] .(2) In a multiple linear step-wise regression analysis, when taking LVMI as dependent variable and other factors as independent variables, we found that hsCRP, SBP, TG, and DBP were main determinants for LVMI.(3) Patients with hypertension were divided into other two subgroups according to LVMI:hypertension with LVH ( group A) and hypertension without LVH(group B).hsCRP of group A was significantly higher than that of group B[(5.9 ± 1.59)mg/L vs (5.0 ±2.23) mg/L,P=0.017].Conclusion Inflammation exists in hypertension patients and becomes worse in hypertension patients with LVH.Inflammation and serum lipid level influence LVH in patients with hypertension.
Keywords：HypertensionHypersensitive C-reactive protein(hsCRP)Serum lipidLeft ventricular hypertrophy( LVH)
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 133-136 )