Clinical significance of plasma ionized calcium and total calcium measurement in the diagnosis of tumor-asso-ciated hypercalcemia
BI Yan-mei
Abstract：Objective To evaluate the clinical significance of plasma ionized calcium( ICa) and total calcium( TCa) measurement in the diagnosis of tumor-associated hypercalcemia.Methods The heparin lithium anticoagula-ted plasma were collected and measured with ion selective electrode ( ISE ) and orthocresolphthalein complexone ( OCPC) method for ICa and TCa in 60 patients with malignant tumor( research group) and 50 healthy people( control group) .Plasma albumin and pH value were measured to correct TCa( cTCa) and ICa( nICa) .Results The levels of cTCa,ICa and nICa in research group were significantly higher than those in control group [(2.56 ±0.20)mmol/L vs (2.31 ±0.11)mmol/L,(1.15 ±0.22)mmol/L vs (1.01 ±0.30)mmol/L and (1.30 ±0.11)mmol/L vs (1.18 ± 0.02)mmol/L,respectively;(P<0.05)],but there was no significant difference in TCa between two groups[(2.41 ± 0.02)mmol/L vs (2.43 ±0.12)mmol/L,(P>0.05)].In the research group,when taking nICa>1.35 mmol/L or cTCa>2.70 mmol/L as the hypercalcemia critical value,the positive rate of nICa and cTCa were 18.33%(11/60) and 6.67%(4/60),respectively,the difference was significant(χ2 =9.458,P=0.036).Conclusion Determination of ICa may be more clinical meaningful than TCa for tumor-associated hypercalcemia.
Keywords：NeoplasmsHypercalcemiaTotal calciumIonized calcium
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 41-43 )