Study on the relationship between expression of gene P53 and sensitivity of esophageal carcinoma to concur-rent radiotherapy and chemotherapy
Abstract：Objective To explore the relationship between gene P53 expression and sensitivity of esophageal carcinoma to the concurrent radiotherapy and chemotherapy,and provide a prediction for the treatment of esophageal car-cinoma.Methods The expression of P53 mRNA in peripheral blood leukocytes of 50 patients with esophageal carcino-ma was detected by RT-PCR( reverse transcription-PCR) method.Patients were treated by 60~70 Gy radiotherapy and two cycles of conventional synchronous DF(fluorouracil and cisplatin) chemotherapy.The relationship between P53 gene expression and therapeutic effect of radiotherapy with concurrent chemotherapy was analyzed.Results The group of P53-positive patients(n=18) showed complete recovery(CR) in 4 cases, partly recovery(PR) in 8 cases, stability (SD) in 4 cases, progression of disease(PD) in 2 cases.The group of P53-negative patients(n=32) showed CR in 11 cases,PR in 20 cases,SD in 1 case, none of PD case.The efficacy of P53-negative patients was significantly better than that of P53-positive patients( P<0.05) .Conclusion The over-expression of P53 gene may influence the sensitivity of tumor cells to radiotherapy and chemotherapy.Therefore, detecting the expression of P53 gene may help to determine the response of esophageal carcinoma to the radiotherapy and chemotherapy, and to determine the prognosis of patients.It has a value for clinical cancer therapy.
Keywords：Esophageal carcinomaP53Gene expressionPolymerase chain reaction( PCR)
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 29-32 )