Correlation analysis between risk factors in second trimester pregnant women and pereclampsia

doi:10.3969/j.issn.1674-3806.2015.01.05

Abstract：Objective To explore the correlation between main risk factors in second trimester pregnant women and preeclampsia( PE) .Methods Three hundred and twenty pregnant women were included in the study, and their general physical examination data were recorded,such as age,weight gain,mean arterial blood pressure etc. Automatic biochemistry analyzer was used to determinate the levels of serum total calcium( [ TCa] o ) and ionized cal-cium( [ Ca2+] o) .The suppression function of CD4 +CD25 +Tregs was detected by enzyme-linked immunosorbent as-say.The pregnant women were followed up until delivery , and were divided into PE group and control group( pregnant women without PE).The correlation of these indexes and PE was observed .Rseults (1) Follow-up outcomes: a-mong 320 pregnant women,27 cases developed PE( PE group) ,the incidence was about 8.44%, including 21 cases of mild PE, 6 cases of severe;293 cases had normal delivery(normal group).(2)Compared with the normal group, mean arterial blood pressure was higher in the PE group; serum [ TCa] o , serum [ Ca2+] o and Treg inhibition rate were lower(P<0.05).There were no significant differences in age, weight gain(P>0.05).In severe PE group ser-um [Ca 2+] owas lower than that in mild PE group, the difference was statistically significant (P<0.05).(3)Corre-lation between levels of serum[ TCa] o,serum[ Ca 2+] o and CD4 +CD25 +Treg inhibition rate:the Pearson coefficients of serum[TCa ]o,serum[Ca2+]o and CD4 +CD25 +Treg inhibition rate were r1 =0.031,P=0.585;r2 =0.129,P=0.021, respectively, indicating that there was no correlation between TCa levels in serum and Treg inhibition rate but that there was a positive correlation between serum[ Ca2+] o and Treg inhibition rate.Conclusion Insufficient serum [ TCa] o ,serum[ Ca2+] o, deficient CD4 +CD25 +Treg inhibition function and increased mean arterial pressure are in -dependent risk factors of PE in the second trimester pregnant women.There was a close positive correlation between serum [ Ca2+] o and CD4 +CD25 +Treg inhibition rate.