Chinical analysis of probiotics combined with prebiotics in the treatment of elderly patients with chronic func-tional constipation
WANG Xiao-guang
SHI Zhen-dong
WANG Guo-jiang
Abstract：Objective To explore the efficacy and safety of probiotics (bifidobacterium tetravaccine tablets ) combined with prebiotics ( lactulose oral liquid ) in the treatment of elderly patients with chronic functional constipation (CFC).Methods Two hundred and sixteen elderly patients with CFC were randomly divided into two groups .One hundred and ten patients in group A were given probiotics combined with prebiotics , One hundred and six patients in group B were given prebiotics ,the treatment course lasted for 4 weeks.The clincal efficacy and safety of the two groups were compared.Results In group A,marked effect was found in 83 patients, effective in 25 patients,ineffective in 2 patients.In group B,marked effect in 69 patients,effective in 21 patients ,ineffective in 16 patients.The clinical effi-cacy in group A were better than those in group B ( P<0.05 ) .During 12 weeks the recurrence rate in group A was 7.4%and that in group B was 21.1%( P<0.05 ) ,and the incidence of adverse reaction in group A was 8.2%and that in group B was 14.2%( P<0.05 ) .Conclusion The effect of probiotics combined with prebiotics is better than prebiotics alone in the treatment of elderly patients with CFC with less adverse drug reaction .
Keywords：Chronic functional constipationElderly patientsBifidobacterium tetravaccine tabletsLactulose and liquid
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1150-1152 )