Analysis of drug resistance and resistance phenotypes of Elizabethkingia meningoseptica
Abstract：Objective To investigate drug resistance and resistance phenotypes of Elizabethkingia meningo-septica(EME).Methods The drug resistance rates of 30 strains to 22 antibiotics were detected by MIC and disk dilu-tion method.Phenotypes of extended spectrum β-lactamase(ESBLs), Ampc and metallo β-lactamase(MBL) were de-tected by disk diffusion and modified three dimension test .Results The drug resistance rates of 30 strains toβ-lactam grop drugs were above 70%, all strains were more susceptible to trimethoprim-sulfa(SXT), ciprofloxacin, levofloxacin, piperacillin/tazobactam, cefoperazone/sulbactam.The drug resistance rates to vancomycin and rifampi were 23.3%and 16.7%respectively.All the isolates were detected to have ESBLs but no Ampc , 18 strains(60.0%) had MBL.Con-clusion EME was multi-drug resistance , it can produce ESBLs and MBL .While ESBLs was most responsible for the resistance to β-lactam group drugs .EME was more resistance to imipenem and meropenem which were used to cure most of the gram negative bacilli , but more susceptible to vancomycin and rifampin which were used to cure most of the gram positive coccus.SXT, minocycline,β-lactamase inhibitor and quinolones drugs may be the best choice for its in-fection.
Keywords：Elizabethkingia meningoseptica(EME)Multi-drug resistanceExtended spectrum β-lacta-mase(ESBLs)Metallo β-laetamase(MBL)
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1113-1117 )