Study on the relationship between antinuclear antibody fluorescence model, specific antibodies spectrum, ti-ter and autoimmune diseases
Abstract：Objective To investigate the relationship between antinuclear antibody ( ANA ) fluorescence model, specific antibodies spectrum, titer and autoimmune diseases(AID).Methods Four hundred and four pa-tients with AID were investigated by using indirect immunofluorescence assay to detect ANA, at the same time, using Europe and Mongolia blotting to detect 15 specific antinuclear antibodies spectrum ( ANAS), and a comparative analy-sis was performed of expression of ANA fluorescence model and the titer and ANA fluorescence model in different dis -eases.Results In AID group the positive rate of ANA was 68.81%, titers in 1∶1 000 accounted for 75.90%.ANA fluorescence model mainly showed cytoplasmic type and nuclear homogeneous type, 130 cases and 108 cases respec-tively.In ANA positive patients, the titer of ANA was higher and fluorescent hybrid model was also increased. Con-clusion The detection rate of ANA was higher in patients with AID. In fluorescent ANA positive patients with high titer the fluorescence model mainly is hybrid model. The simultaneous detection of ANA and ANAS has important clinical significance for diagnosis of autoimmune diseases.
Keywords：Antinuclear antibody fluorescence modelAntinuclear antibodiesIndirect immunofluores-cenceLine immunoassay
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1006-1009 )