Influence of hyperthermic perfusion chemotherapy on immune indexes in patients with colorectal cancer

PANG Li-ming; LI De-gang; WU Wei

doi:10.3969/j.issn.1674-3806.2014.11.04

Abstract：Objective To evaluate the influence of intraperitoneal hyperthermic perfusion chemotherapy on immune indexes in peripheral blood in postoperative patients with colorectal cancer .Methods From January 2010 to December 2013 ,50 patients with DukesB~C colorectal cancer were randomly divided into two groups:the hyperther-mic perfusion chemotherapy group and the normal temperature perfusion chemotherapy group .After surgery hyperther-mic perfusion chemotherapy group received intraperitoneal hyperthermic distilled water (43~45 ℃) perfusion contai-ning fluorouracil(5-FU)0.5 g/L,mitomycinC(MMC) 8 mg/L oxaliplatin 25 mg/L in 4 000 ml distilled water for 1 hour;the normal temperature perfusion group received intraperitoneal normal temperature distilled water (25~30℃) perfusion containing above drugs in 4 000 ml distilled water for 1 hour.The same perfusions were performed at 1 and 2 months after operation in two groups .Before operation ,during operation and at 1 and 2 months after operation IL-2 and TNF-αin peripheral blood were measured by ELISA in two groups .Results Compared with normal temperature perfusion chemotherapy group ,the levels of IL-2 and TNF-αin hyperthermic perfusion chemotherapy group were sig-nificantly increased ,and the difference was statistically significant ( P<0.05 ) .Conclusion Intraperitoneal hyper-thermic perfusion chemotherapy may promote Thl-type immune drift , enhance the body′s anti-tumor immune function , and have a certain role in prevention and treatment of the peritoneal recurrence and metastases of colorectal cancer .