Screening and related factors of mild cognitive impairment in patients with Parkinson′s disease
Abstract：Objective To explore the screening methods and the related factors of mild cognitive impairment (MCI) in patients with Parkinson′s disease(PD).Methods Montreal Cognitive Assessment(MoCA)(Beijing Ver-sion) was used as cognition assessment implement.Thirty-eight PD patients with mild cognitive impairment were cho-sen as research group( MCI group) , and 30 PD patients with normal cognitive function was chosen as control group. In all subjects the creatinine( CREA) , Triglyceride( TG) , cholesterol( CHOL) , high density lipoproteins( HDL-C) , alanine transarninase(ALT), glutamic-oxalacetic transaminase(AST) was measured.Results (1)Between MCI group and control group:there were significant differences in the duration of PD,BMI,abdominal perimeter,LDL-C, HDL-C, CHOL(P<0.05) and no significant differences in TG,ALT,AST and CREA.(2)There was negative corre-lation between the MoCA scores and the LDL-C in MCI group(r=-0.255,P<0.05).Conclusion The risk factors such as longer duration, obesity and high level of blood fat contribute to the development of cognitive impairment and may even aggravate it.So reduction of body weight and control of blood fat may help to improve the cognitive func-tion.
Keywords：Parkinson′s disease(PD)Mild cognitive impairment(MCI)Montreal cognitive assess-mentAlzheimer′s disease(AD)
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 938-941 )