R eal tion be tweens erum Ghrelin levle a nd insulin resistance in infertility patei nts with PCOS
Abstract：Objective To explore the relationship between serum Ghrelin level and insulin resistance in in-fertility patients with PCOS.Methods Ninety-eight cases of PCOS ( PCOS group) and seventy-two cases of non PCOS ( non PCOS group) for first time visiting our hospital due to infertility from January 2010 to December 2012 were se-lected.The BMI, serum Ghrelin level, and the related anthropometric indexes were detected.Results The serum Ghrelin levels in PCOS patients were lower than non PCOS patients [ ( 442.56 ±221.71 ) pg/ml vs ( 697.41 ± 157.84)pg/ml, P<0.05].The HOMA-IR was higher in PCOS group compared to non PCOS group[(3.84 ±1.23) vs (2.14 ±0.77), P<0.05].Pearson correlation analysis showed that serum Ghrelin level was negatively correlated with HOMA-IR in PCOS patients(r=-0.48, P<0.01).Conclusion The serum Ghrelin level in infertility pa-tients with PCOS is evidently lower than that in non PCOS infertility patients.Ghrelin level was negatively correlated with HOMA-IR in PCOS patients.Thus indicated that Ghrelin may promote the development of IR in infertility pa-tients with PCOS.
Keywords：Polycystic ovary syndrome(PCOS)Insulin resistance(IR)InfertilityGhrelin
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 902-904 )