Safety and efficacy of intracoronary injection of half dose tirofiban for slow blood flow in elderly patients with myocardial infarction during emergency PCI operation
LIANG Kun
Abstract：Objective To explore the safety and efficacy of intracoronary injection of half dose of tirofiban for the slow flow in elderly patients with acute myocardial infarction during emergency percutaneous coronary interven -tion( PCI) operation.Methods Ninety-eight elderly patients with myocardial infarction who had slow flow during e -mergency PCI operation were randomly divided into A group and B group , with 49 cases in each group , and were giv-en 5 μg/kg and 10μg/kg tirofiban in the coronary artery respectively .Between two groups the plasma C-reactive pro-tein, serum creatine kinase MB and cardiac troponin I , cardiovascular events , bleeding with in 3 days after operation were compared .Results Baseline and third day after operation , the two groups had no statistically significant differ-ence in serum C-reactive protein , serum creatine kinase MB and cardiac troponin I ( P>0.05 ) .Two groups had no decrease in hemoglobin , hematocrit and platelet counts , no allergic reaction was found .2 cases of mild bleeding in A group(4.08%), 3 case of mild bleeding in B group (6.12%), no significant difference between two groups (P>0.05 ) .Conclusion Intracoronary injection of half dose of tirofiban has the exact efficacy on slow flow of elderly my -ocardial infarctionin patients undergoing emergency PCI , and is safe and effective with less adverse reaction , and is worth of clinical application .
Keywords：Coronary arteryTirofiban hydrochlorideEmergency percutaneous coronary intervention (PCI)Acute myocardial infarctionSlow flow
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 829-831 )