Impacts of nasal drop of 1%ephedrine hydrochloride on blood pressure of patients treated with hyperbaric ;oxygen

doi:10.3969/j.issn.1674-3806.2014.09.08

Abstract：Objective To provide a reference for proper use of ephedrine by observing impacts of nasal drop of 1%ephedrine hydrochloride on blood pressure of patients treated with hyperbaric oxygen ( HPO) .Methods Sixty HBO patients were randomly divided into two groups (30 cases for each), i.e.observed group and contrast group. Patients in observed group , before being sent into large medical hyperbaric oxygen tank , were put 1% ephedrine hydrochloride nasal drops three drops into bilateral nasal cavities while those in contrast group won ′t.Their blood pressure were measured at the right upper limb in different period of time , i.e.before HBO, at 20 min of pressuri-zing, at 25 min and 50 min of oxygen inhalation under stable pressure , before finishing of decompressing , at 30 min after HBO.Their blood pressure change were observed and statistical analysis was carried out .Results For systolic pressure and diastolic pressure , there was no significant difference between observed group and contrast group ( P>0.05 ) .The blood pressure of both groups increased first and then decreased during HBO , it had statistical signifi-cance comparing with prior treatment (P<0.05).But there was no interaction between groups and time-points, that showed , impacts on blood pressure treating with or without nasal drop were the same .Conclusion For those patients who is in normal blood pressure ,taking nasal drop of 1%ephedrine hydrochloride three drops into bilateral nasal cavi-ties before HBO does not affect blood pressure .