Value of brachial artery FMD and sCD40L in predicting acute coronary syndrome
Abstract：Objective To investigate the predictive value of ACS by brachial artery FMD and sCD 40L. Methods Thirty-nine healthy volunteers(control group), 39 patients with stable angina pectoris(SA group) and 79 patients with acute coronary syndrome (ACS),including 49 patients with unstable angina pectoris (UA group) and 30 patients with acute myocardial infarction (AMI group), were radomly selected.The patients with ACS were detected the brachial artery FMD by ultrasonic testing and the serum sCD 40L by ELISA.Relation of brachial artery FMD and serum sCD40L of ACS patients were analyzed by using Pearson correlation analysis .Results Compared with control group and SA goup , the brachial artery FMD decreased in UA group and AMI group ( 9.52 ±2.54 )%( control group) vs (5.35 ±1.24)%(SA group) vs (3.32 ±1.41)% (UA group) vs (3.26 ±1.32)%(AMI group), (P<0.05).Compared with control group and SA goup , the serum sCD40L increased in UA group and AMI group (1.21 ± 0.31)ng/ml(control group) vs (4.12 ±0.98)ng/ml(SA group) vs (12.86 ±2.67)ng/ml (UA group) vs (13.95 ± 2.83)ng/ml(AMI group), (P<0.05).Pearson correlation analysis indicted that the brachial artery FMD was nega-tively associated with the level of serum sCD40L in ACS patients (r=-0.708,P=0.000).Conclusion The down-regulation of brachial artery FMD by ultrasound findings and upregulation of serum sCD 40L have predictive value for the occurrence of ACS .
Keywords：Brachial arteryFlow mediated dilatationsoluble CD40 ligand(sCD40L)Acute coro-nary syndrome(ACS)
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 803-805 )