Effects of different doses of atorvastatin on the activity of nuclear factor-kappa B in peripheral blood mono-nuclear cells and urinary albumin excretion rate in the elderly patients with early diabetic nephropathy
Abstract：Objective To observe the effects of different doses of atorvastatin on phosphorylation of nuclear factor-kappa B(NF-κB) P65(ser536) in peripheral blood mononuclear cells , on the levels of serum inflammatory factors,including high sensitivity C reactive protein (hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6 ),interleukin-1β(IL1-β), and on urinary albumin excretion rate(UAER) in the elderly patients with early diabetic nephropathy.Methods The patients(n=72) of type 2 diabetes with early nephropathy were randomly divided into two groups ,The patients were given atorvastatin 10 mg/d in DN1 group and atorvastatin 20 mg/d in DN2 group for sixteen weeks.Levels of NF-κB, serum inflammation factors,UAER,Total cholesterol(TC),triglyceride( TG),low density lipoprotein ( LDL-C) and hight density lipoprotein ( HDL-C) were measured before treatment and after treat-ment for sixteen weeks .Results After sixteen weeks of treatment ,the levels of NF -kB, serum inflammation factors , TC and LDL were reduced(P<0.05 or P<0.01) in two group.DN2 group decreased more significantly.UAER were reduced(P<0.01)in DN2 group.There was no significant changes in DN1 group(P>0.05).Conclusion Atorvastatin can reduce activity of NF-κB, levels of hs-CRP,TNF-α,IL-6,IL-1β,TC, and LDL in the olderly patients with type 2 diabetic pristine nephropathy .Atorvastatin may benefit patients with diabetes mellitus by ameliorating in-flammatory stats, as well as reducing urinary albumin ,in a dose-dependent manner .
Keywords：Diabetic nephropathy ( DN)NF-κBInflammation factorsUrinary albumin excretion rate ( UAER)Atorvastatin
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 799-802 )