Clinical observation of S-1 capsule combined with oxaliplatin in the treatment of advanced gastric cancer
XIA Bao-jun
HUANG Zhi-hu
REN Wu
Abstract：Objective To evaluate the efficacy and toxicity of the combination of S-1 capsule and oxaliplatin in the treatment of advanced gastric cancer .Methods Sixty patients with advanced gastric cancer were divided into two groups:the treatment group(30 cases) and the control group(30 cases).The treatment group were treated with S-1 capsule and oxaliplatin and the control group with oxaliplatin , calcium folinate and fluorouracil .All patients received at least four cycles of chemotherapy .Results The treatment group showed CR in zero patient ,PR in 19 patients,SD in 10 patients and PD in 1 patients,while the control group showed CR in zero patient ,PR in 9 patients,SD in 17 pa-tients and PD in 4 patients .The main side effects were hematological toxicity ,gastrointestinal reaction and nervous sys-tem toxicity.Compared with the control group , the occurrence rate of adverse reactions of the treatment group were significantly lower ( P<0.05 ) .Conclusion S-1 capsule combined with oxaliplatin is safe and effective in the treat-ment of advanced gastric cancer .
Keywords：S-1 capsuleOxaliplatinAdvanced gastric cancerChemotherapy
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 727-729 )