Clinical and pathologic analysis of endometrial lesion in breast cancer patients taking tamoxifen
WANG Ya-li
CHEN Long-zhou
LI Qing-guo
Abstract：Objective To evaluate the effect of tamoxifen (TAM) on endometrium in postoperative breast cancer patients treated with TAM .Methods Edometrial biopsies were performed in 80 patients having abnormal va-ginal bleeding or abnormal thickness of endometrial by ultrasound in TAM group .TAM group was divided into prem-enopausal and menopausal group or two groups including T <2 years and T≥2 years according to the time with tamox-ifen.Results The frequency of endometrial hyperplasia and polyps was higher in TAM group .All the atypical hyper-plasia and endometrioid carcinoma cases occurred in menopausal group .The occurrence of endometrial disease had no relations with the duration of taking TAM .Conclusion Risk of endometrial disease in postoperative breast cancer pa-tients treated with TAM will be increased .More attention should be paid to the patients who were treated with TAM for breast cancer ,and endometrium should be evaluated by pelvic ultrasound before and during TAM usage .
Keywords：TamoxifenEndometriumBreast cancer
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 719-721 )