Analysis of the efficacy of pramipexole in the treatment of 32 cases advanced Parkinson′s disease
Abstract：Objective To explore the efficacy of pramipexole in the treatment of advanced Parkinson′s dis-ease(PD).Methods Thirty-two PD patients with Hoehn-YahrⅣ~Ⅴhas been treated with levodopa more than 2~6 years as the research object .Pramipexole was added , and evaluated the curative effect after 12 weeks.Motor symp-toms:PD rating scale(UPDRS) was used to evaluate treatment effect;Non-motor symptoms: the changes were ob-served of the anxiety , depression, sleep disorder symptoms , and adverse reactions of patients were recorded .Results The UPDRS scores of PD patients significantly decreased after treatment , and the difference was statistically signifi-cant(P<0.01).All the patients has not suffered from serious adverse reactions in the process of treatment .Conclu-sion For advanced PD patients adding pramipexole treatment on the basis of levodopa can effectively alleviate the motor symptoms and non-motor symptoms, obviously improve the quality of life at the same time .
Keywords：Parkinson′s disease(PD)PramipexoleLevodopa
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 717-719 )