Preparation of PLA-Rifapentinum microspheres and the effect of lung targeting in mice
Abstract：Objective To prepare PLA-Rifapentinum microspheres(RifapM) for lung targeting and evaluate it′s rule of rifapentinum release and lung targeting in mice .Methods Solvent volatilization was used to prepare lung targeting RifapM,and dynamic dialysis method was adopted to observe the rule of rifapentinum release .In vivo distri-bution was studied .Results The diameters of 81.6% microspheres were between 7~30 μm,the average diameter was (14.2 ±3.1)μm.Entrapment efficiency was 78.39%.The drug supporter in microspheres was (39.6 ±3.6)%(n=5).The invitro release T50 was 68 min, and was 4.5 times more than that of the control group .The relative dis-tribution percentage of RifapM in lung after iv administration to mice was significantly higher than those in other tis -sues and blood ,and was 3.3 times more than control group .Conclusion RifapM have evident sustained-release and lung targeting .
Keywords：RifapentinumPLA-microspheresLung targetingSustained-release
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 714-716 )