Diagnosis and treatment analysis of 38 cases of neurosyphilis and literature review

doi:10.3969/j.issn.1674-3806.2014.08.06

Abstract：Objective To investigate the clinical characteristics laboratory examination , early diagnosis , the basis of classification and treatment of the patients with neurosyphilis .Methods The data of 38 patients with neu-rosyphilis from September 2004 to January 2014 in Fourth People′s Hospital Affiliated to Jiangsu University , Zhen-jiang First People′s Hospital and the Fourth People′s Affiliated Hospital of Jiangsu University were analyzed retrospec-tively.Results In this group, there were 38 patients, male 28 cases, female 10 cases, age 1~75 years old, mean 51.1 years, including 10 cases of interstitial neurosyphilis (8 cases of meningovascular neurosyphilis , 1 cases of spi-nal meningovascular neurosyphilis , 1 patients with meningeal neurosyphilis ), 22 cases of parenchyma type (14 cases of paralytic dementia , 8 cases of tabes dorsalis ) , 2 case of optic nerve injury , 3 cases of asymptomatic neurosyphilis , 1 cases of congenital syphilis;serum, CSF RPR and TPPA in all patients were positive .In part of patients cerebro-spinal fluid examination showed elevated cerebrospinal fluid protein content , the increased white blood cell count ( mainly monocytes ) .Except 3 cases giving up treatment , 35 cases recovered after treatment , the serum antibody titre and CSF antibody titers were reduced to varying degrees , CSF white blood cell count , protein decreased to normal . Conclusion Neurosyphilis is preventable and curable , cerebrospinal fluid test for syphilis is an important basis for the diagnosis of neurosyphilis , but it is necessary to make a comprehensive analysis based on clinical manifestations , other examination in order to obtain the final diagnosis , and correct and timely treatment can control the disease .