Analysis on the survival condition and its influence factors of 305 hospitalized patients with AIDS

doi:10.3969/j.issn.1674-3806.2014.08.02

Abstract：Objective To understand the survival situation and its influencing factors in patients with AIDS , to explore the strategy prolonging the survival time of patients with AIDS .Methods Clinical data of 305 of AIDS pa-tients from January 2010 to December 2012 were retrospectively analyzed , and the COX proportional hazard model was used to analyze the risk factors affecting survival rate .Results At the end point of the study ,of 305 patients, 204 patients (66.9%) died, 101 patients (33.1%) survived.At 1~3 months the cumulative survival rates were 45%, 25%, 11%respectively.The median survival time was 27.4 d.Multivariate COX proportional hazard model analysis showed that the risk of death in patients were infected via sexual transmission and other ways was lower than that in patients were infected via intravenous route ( HR=0.878 , HR=0.373 ) .The risk of death in patients with higher baseline of CD4 +T lymphocyte count was lower than that in patients with lower baseline of CD 4+T lymphocyte count(HR=0.157, HR=0.423).The patients received antiviral treatment at admission had lower risk of death (HR=0.378 );The patients with fever ( HR=3.033 ) , and associated encephalopathy ( HR=1.678 ) at admission had higher risk of death .Conclusion AIDS hospitalization survival time is relatively short , the route of infection , baseline of CD4 +T lymphocyte count , whether fever at admission , whether merger AIDS-associated encephalopathy , and wheth-er use the antiviral treatment is the main factors influencing the survival time of hospitalization .