Control study of venlafaxine versus paroxetine in the treatment of generalized anxiety disorder
Abstract：Objective To compare the effect , social function and safety of venlafaxine versus paroxetine in the treatment of general anxiety disorder .Methods Sixty-eight patients with generalized anxiety disorder were ran-domly divided into two groups .The observation group was given venlafaxine , the control group was given paroxetine for 6 weeks.The Hamilton Anxiety Scale(HAMA),global assessment function(GAF) and side effects scale(TESS) were used to assess the therapeutic effects before treatment and at the end of the 1st,2nd,4th,6th week after treat-ment, respectively.Results There was declined trend in HAMA′s total scores, mental anxiety scores and somatic anxiety scores in two groups .The MAMA′s total scores, mental anxiety scores at every time points after 1st week′s treatment and the HAMA′s somatic anxiety somatic anxiety scores at every time points after 2nd week′s treatment were significantly decreased in the observation group compared with those before treatment ( P<0.05 ) .The HAMA′s total scores, mental anxiety scores at every time points after 2nd week′s treatment, the HAMA′s somatic anxiety scores at every time points after 4th week′s treatment were significantly decreased in the control group compared with those be-fore treatment ( P<0.05 ) .There was no statistically difference in the main effect of HAMA′s scores between two groups(P >0.05).The declined amplitude in HAMA scores in the observation group was significantly greater than that in the control group ( P<0.05 ) .There was an ascended trend in GAF′s scores in two groups .The GAF′s scores at every time points after 1st week′s treatment were significantly increased compared with those before treatment (P<0.05 ) ,but there were no statistically difference in the main effect of GAF′s scores and the ascended amplitude in GAF′s scores between two groups ( P>0.05 ) .There were no statistically difference in the rate of adverse reaction and the use of diazepams ( P>0.05 ) .Conclusion Using venlafaxine and paroxetine for treating generalized anxiety dis-order are effective and safe , but venlafaxine acts more rapidly and more improves the somatic symptoms compared with paroxetine .
Keywords：VenlafaxineParoxetineGeneralized anxiety disorder ( GAD)
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 587-590 )