Application of high-frequency oscillatory ventilation in meconium aspiration syndrome
FENG Cheng-fang
LIAO Pei-guang
Abstract：Objective To evaluate the efficiency of conventional mechanical ventilation ( CMV) and high-frequency oscillatory ventilation ( HFOV) in the treatment of neonates meconium aspiration syndrome ( MAS) .Meth-ods Sixty neonates with MAS were randomly divided into CMV group (30 cases) and HFOV group(30 cases).The parameter of pH , PaO2 , PaCO2 , FiO2 ( inhaled oxygen concentration ) ,OI( oxygen index ) were monitored before and after mechanical ventilation .Complications and clinical outcomes were compared .Results The pH, PaO2 , PaCO2 , FiO2, OI at 0 h between the two groups were not statistically significant difference (P>0.05).At 2 hours, 12 hours, 24 hours,48 hours after ventilation , pH, PaO2 , PaCO2 , FiO2 , OI in the HFOV group improved more quickly than those in the CMV group , with statistically significant difference ( P<0.05 ) .Mechanical ventilation time in the HFOV group was more shorter than that in the CMV group , with statistically significant difference (t=3.197,P=0.002). The complications of mechanical ventilation hade statistically significant difference between two groups (χ2 =4.043,P=0.044).The cure rate had statistically significant difference between two groups (χ2 =4.320,P=0.038).Conclu-sion HFOV is a safe and effective means for the treatment of severe MAS .
Keywords：NeonateRespiratory failureMeconium aspiration syndrome(MAS)High-frequency os-cillatory ventilation(HFOV)Conventional mechanical ventilation(CMV)
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 437-440 )