Observation on the changes of urine microprotein in patients with Graves disease before and after cured with 131 I

doi:10.3969/j.issn.1674-3806.2014.05.14

Abstract：Objective To investigate the influence factors of the urine microprotein in the patients of Graves disease(GD) before and after cure with 131iodine(131I).Methods Twenty patients with GD were treated with 131I and 20 healthy person were used for normal control group (NG).The patients with GD were divided into GD group (before treatment with 131I), R3M group(3 months after of cure with 131I and R12M group(12 months after cure with 131 I) .The following biomakers were observeed in the above groups:3 free thyroid functions [ free three triiodothyro-nine(FT3), free thyroxine(FT4) and thyroid stimulating hormone(TSH)], thyrotropin receptor antibody(TRAb), urinary microalbumin(Alb), urine immunoglobulin(IgG) and urine β2-microglobulin(β2-MG) were measured by automatic chemical immune chemiluminescence .Serum high sensitivity C-reactive protein(hS-CRP) was detected by the scattering ratio.D-dimer was examined with Rate Nephelometry .And the total glomerular filtration rate ( TRGFR) was calculated by SPECT .Results There was a significant difference in 3 free thyroid functions in GD group com-pared with those in R3M group, R12M group and in NG(P<0.01).A significant difference of TRAb, urine Alb and IgG was observed in the GD group and R3M compared with those in R12M and in NG(P<0.01).Linear correlation analysis showed that there was significant positive correlation between FT 3 and Alb, IgG(r respectively were 0.64, 0.72 , P all <0.01 ) , TRAb was significantly positive correlated with Alb , IgG( r respectively were 0.66 , 0.56 , P all <0.01 ) .Conclusion The kidney damage of GD occurs in the glomerulus and it is closely related to immune dis -orders.The disappearance of the hyperthyroidism-related antibodies can be used as the effect reference index in the assessment of recovery and treatment of GD renal damage .