Application of artificial dermis combined with autologous thin layer skin grafts in repairing the refractory wounds

doi:10.3969/j.issn.1674-3806.2014.05.12

Abstract：Objective To observe the effects of artificial dermis combined with autologous thin layer skin grafts(composite skin) in repairing the refractory wounds.Methods Thirty patients with refractory wounds were in-volved who had deep skin soft tissue defect , some cases complicated with exposure of muscles , tendons, bone.All of refractory wounds were repaired by the technology of combining artificial dermis with autologous thin skin transplanta -tion.The technology included 2 steps:firstly, artificial dermis were transplanted on all refractory wounds after the de-bridement , then autologous thin layer skin were transplanted on artificial dermis 2~3 weeks after debridement , at that time the dermal tissue growing well and covering exposed tendon , bone tissue .Then the survival rate of artificial dermis and composite skin , the degree of scar hyperplasia , pigmentation change and joint activity were observed to e-valuate the effects of composite skin repairing refractory wounds .Results In 25 of 30 patients artificial dermis were survival after transplantation,the survival rate was 83.3%(25/30), the causes of 5 cases failure included local infec-tion 4 cases and instability separately 1 case.The survival rate of composite skin was 100.0%(25/25).The compos-ite skin showed smooth and flexible , no obvious change of scar hyperplasia and pigment on the area of composite skin and doner skin during of follow-up 2~6 months after discharge .Conclusion The advantages of composite skin graft-ing were included high survival rate and well texture , no significant change of scar hyperplasia and pigment on the ar-ea of composite skin and doner skin , easily operation .