Clinical application value of intensive insulin therapy in severe traumatic brain injury
Abstract：Objective To discuss the clinical application value of intensive insulin therapy ( IIT) in severe traumatic brain injury(sTBI).Methods Two hundred patients with sTBI (GCS 3~8) were randomly divided into the intensive insulin therapy group(IIT,n=100 cases)and the conventional insulin treatment group (CIT,n=100 ca-ses) .IIT group′s blood glucose ( BG) was controlled in 3.9~6.1 mmol/L, CIT group′s blood glucose was controlled in 8.3~10.1 mmol/L.The patients after admission were treated using continuous intravenous infusion of insulin to control blood glucose .The average blood glucose levels , insulin dosage , incidence of hypoglycemia in two groups were recorded .Six months after injury , the efficacy was evaluated according to GOS valuation method including 5 grades:good, moderate disability, severe disability, vegetative state, and death.Results During treatment BG in IIT group was lower than that in CIT group ( P<0.01 ) , the incidence of hypoglycemia , average hourly insulin dosage in IIT group were higher than those in CIT group ( P<0.05 or P<0.01 ) .After 6 months there were no statistically signifi-cant difference between the two groups in the efficacy including good , moderate disability , severe disability , vegeta-tive state, and death(P>0.05).Conclusion IIT does not improve the prognosis of patients with sTBI , but increase the incidence of hypoglycemia , blood glucose is controlled in 8.3~10.1 mmol /L is ideal.
Keywords：Severe traumatic brain injury(sTBI)Intensive insulin therapy(IIT)Blood glucose(BG)Prognosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 421-423 )