Effect of the beraprost sodium on serum cystatin C, urinary microalbumin excretion rate and vascular endo-thelial function in patients with early diabetic nephropathy
Abstract：Objective To investigate the effect of the beraprost sodium on serum cystatin C, urinary mi-croalbumin excretion rate and vascular endothelial function in patients with early diabetic nephropathy .Methods Fif-ty-eight patients with early diabetic nephropathy were selected and randomly divided into 2 groups(control group with 30 cases and treatment group with 28 cases).Control group was treated with insulin,low-protein diet,control blood pressure;the treatment group was treated with beraprost sodium 40 μg tid on the basis of normal treatment for 12 weeks.The endothelium-dependent flow-mediated dilatation(FMD) of brachial artery was determined with ultrasound , and the levels of endothelin-1(ET-1), Glycated hemoglobin(HbA1c), triglycerides(TG), total cholesterol(TC), high-density lipoprotein cholesterol ( HDL-C) , low density lipoprotein cholesterol ( LDL-C) , 24 h urinary albumin ex-cretion rate(UAER), serum cystatin C(Cys-C), endogenous creatinine clearance (Ccr) were measured respectively before and after treatment .Results There was no statistically significant difference of blood sugar ,blood pressure, blood lipid before and after treatment (P>0.05).After treatment,the levels of UAER, Cys-c and ET-1 in treatment group were significantly lower than those of the control group ( P<0.05 ) , the levels of Ccr and FMD in treatment group were increased more significantly than control group ( P<0.05 ) .Conclusion The beraprost sodium can effec-tively reduce the levels of UAER , Cys-C and recovery renal vascular endothelial function in the patients with early di -abetic nephropathy .
Keywords：Beraprost sodiumDiabetic nephropathies ( DN)Endothelial dysfunction
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 317-320 )