Clinical analysis of parameter of pulmonary ventilation function in asthmatic children

doi:10.3969/j.issn.1674-3806.2014.04.10

Abstract：Objective To study the role of parameters of pulmonary ventilation function in assessing asth-matic status and instructing treatment by measuring parameter of pulmonary ventilation function in children with asth -ma in acute exacerbation and remission .Methods Forty three(5 to 12 years old) children with asthma both in acute exacerbation and in remission after treatment were studied .Pulmonary ventilation function parameters including large-airway pulmonary function values ( FVC, FEV1, FEV1/FVC, PEF) and small-airway pulmonary function measure-ments(FEF25, FEF50, FEF75, MMEF75/25) in all subjects were measured in stage of asthma attack and in remis-sion after treatment respectively by using Jaeger Master Screen diffusion determinator .Also the date of medical history and treatment of asthmatic children was collected at the same time .Results There were statistically significant that pulmonary ventilation function parameters FVC , FEV1, FEV1/FVC, PEF of asthmatic children in acute exacerbation were decreased as compared to that of those in remission and healthy children group ( P<0.01 ); while pulmonary ventilation function parameters including FVC , FEV1, PEF in remission children after therapy with asthma were nor-mal comparing to those of healthy children group (P>0.05).The small airway function parameters FEF25, FEF50, FEF75, MMEF75/25 in children with acute asthma were obviously decreased , which be significantly different from that of those in remission and healthy children (P<0.01);the parameters of FEF25, FEF50, FEF75, MMEF75/25 in asthmatic children of catabasis were lower significantly than that of those in healthy children ( P<0.05 ) .The lower each index of pulmonary ventilation function parameters ( FVC%pred, FEV1% pred, PEF%pred, FEF25%pred, FEF50%pred, FEF75%pred, MMEF75/25%pred) and the more severe in episode in asthmatic children , there were significant difference ( P<0.05 ) .Conclusion There was likely to that the parameters of pulmonary ventilation func-tion in asthmatic children of acute exacerbation were impaired .The parameters of small airway function were still de-creased in asthmatic children in remission after therapy , while that small-airway pulmonary ventilation function pa-rameters were more importance in assessing the state of asthma which could instruct treatment for asthma in children .