Screening serum differential proteins with relation to the high-risk and no-risk familial pedigree for liver cancer by SELDI-TOF-MS
Abstract：Objective To compare serum protein pattern of patients with liver cancer from high-risk families for liver cancer with that of patients with liver cancer from no-risk familial pedigree for liver cancer and detect specific biomarkers in serum between two groups .Methods SELDI-TOF-MS Protein Chip was used to detect serum protein patterns of 25 patients with liver cancer from high-risk familial pedigree for liver cancer and 25 patients with liver cancer from no-risk families for liver cancer .Diagnostic model was developed and validated by using BPS .Results At the molecular weight range from 2 000 to 50 000 ,15 protein peaks were obviously different between two groups .Ana-lyzed by BPS, the diagnostic model′s accuracy was 92.0%(46/50),sensitivity was 96.0%(24/25) and specificity was 88.0%(22/25).Conclusion There are amount of the special serum differential proteins between two groups ,SELDI-TOF-MS Protein Chip array technology has better clinical value in detecting the special serum protein biomarkers .
Keywords：Liver cancerFamilial pedigreeSurface enhanced laser desorption ionization time of fight mass spectrometry ( SELDI-TOF-MS)Serum protein biomarker
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 185-187 )