High initial concentration sevoflurane for inhalational induction of general anaesthesia:a prospective research
CHEN Zu-tao
PENG Hui-li
WANG Peng
Abstract：Objective To investgatd the safety and efficacy of the high initial concentration sevoflurane for inhalational induction of general anaesthesia .Methods Three hundred adult patients undergoing elective surgery an-esthesia , ASAⅠ~Ⅱ, were randomly divided into two groups according to odd or even number of operative date .The low initial concentration group (179 cases) was initially administered a low concentration of sevoflurane then the con-centration was gradually increased until the patient was anaesthetized .The high initial concentration group ( 121 ca-ses) was administered high concentrations of sevoflurane ( from 4%to 8%) from the beginning , continuing until the patients was anaesthetized .Both techniques can be carried out using different breathing patterns .Time to loss of eye-lash reflex(LOER)(seconds), complication rates in the two groups were recorded .Results Time to LOER in high initial concentration group was obviously shorter than the lower initial concentration groups , the differences were statis-tically significant (P<0.01).There was no difference in the incidence of adverse effects between the two groups (P>0.05 ) .Conclusion Compared with low initial concentration of sevoflurane a high initial concentration sevoflurane probably offers more rapid induction of anaesthesia and a similar rate of complications , especially worth promoting .
Keywords：SevofluraneAnesthetic inductionAdverse effects
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 144-146 )