Observation on curative effects of cord blood cytokine-inducedkiller cells combined with gemcitabine and ci s- platin in the treatment of advanced non-small cell lung cancer patients

LANG Bo; YANG Xiu-zhi

doi:10.3969/j.issn.1674-3806.2014.02.09

Abstract：life,to analyze the clinical value .Methods Fifty-two patients with advanced non -small cell lung cancer were ran-domly divided into two groups .There were 25 patients in the observation group , 27 patients in the control group .The observation group were treated by GP plus CIK cell immunotherapy program and the control group of 27 patients were treated by GP program .Efficacy and adverse reactions were evaluated .QLQ-LC13 scale was used before and after treatment to assess the quality of life .Results The observation group showed PR in 6 cases, SD in 10 cases, PD in 9 cases, the control group showed PR in 3 cases, SD in 7 cases, PD in 17 cases.The difference between the two groups was statistically significant( P<0.05 ) .After treatment , the life quality scores in the observation group was better than that in the control group ( P<0.05 ) .The adverse reaction in the observation group was lower than the control group(P<0.05).In the observed group, the probability of fever was higher than that of the control group (P<0.05 ) .Conclusion The treatment of cord blood cytokine -induced killer cells combined with gemcitabine and cispl-atin for advanced non-small cell lung cancer patients is safe and effective .It can improve quality of life of the patients with advanced non-small cell lung cancer .The treatment will be worth popularizing in clinical applications . <br> Objective To observe the efficacy of cord blood cytokine-induced killer cells combined with gemcitabine and cisplatin in the treatment of advanced non-small cell lung cancer ,and to study patients′quality of life,to analyze the clinical value .Methods Fifty-two patients with advanced non -small cell lung cancer were ran-domly divided into two groups .There were 25 patients in the observation group , 27 patients in the control group .The observation group were treated by GP plus CIK cell immunotherapy program and the control group of 27 patients were treated by GP program .Efficacy and adverse reactions were evaluated .QLQ-LC13 scale was used before and after treatment to assess the quality of life .Results The observation group showed PR in 6 cases, SD in 10 cases, PD in 9 cases, the control group showed PR in 3 cases, SD in 7 cases, PD in 17 cases.The difference between the two groups was statistically significant( P<0.05 ) .After treatment , the life quality scores in the observation group was better than that in the control group ( P<0.05 ) .The adverse reaction in the observation group was lower than the control group(P<0.05).In the observed group, the probability of fever was higher than that of the control group (P<0.05 ) .Conclusion The treatment of cord blood cytokine -induced killer cells combined with gemcitabine and cispl-atin for advanced non-small cell lung cancer patients is safe and effective .It can improve quality of life of the patients with advanced non-small cell lung cancer .The treatment will be worth popularizing in clinical applications .