The observation on the efficiency and safety of oral ibuprofen in the treatment of premature infant with neo- natal respiratory distress syndrome combined with patent ductus arterious
Abstract：Objective To investigate the efficiency and safety of oral ibuprofen in the treatment of premature infant with neonatal respiratory distress syndrome ( NRDS) combined with patent ductus arterious ( PDA) .Methods Thirty-eight cases were included .The birth weight was between 920 g and 2 900 g, gestation age was between 26.57 weeks and 63.29 weeks.Ibuprofen suspension was given with dosage 10 mg/kg for 3 times.The heart rate, SaO2, blood pressure , blood glucose , urine output , bilirubin and electrolyte were monitored during the treatment .The renal function, CBC, bilirubin and echocardiogram were examined before and after the treatment. Re sults PDA was closed in 32 cases(84.21%).CBC, bilirubin, urine output, and serum creatinine did not show significant changes . The changes of CBC, bilirubin, urine output, renal function was not related with neither birth age , birth weight, days of breath support , method of breath support , day of drug given nor whether the application of pulmonary surfactant . Conclusion Oral ibuprofen is effective and safety in closing PDA in premature infant with NRDS .
Keywords：Premature infantNeonatal respiratory distress syndromePatent ductus arteriousIbu-profen
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 118-121 )