Study on the relationship between serum TNF-α, IL-1β, Osteoprotegerin and type 2 diabetes mellitus with coronary artery disease
Abstract：Objective To investigate the relationship between tumor necrosis factor-α(TNF-α),Interleukin-1β(IL-1β),Osteoprotegerin(OPG)and type 2 diabetes mellitus(T2DM) with coronary artery disease(CAD).Meth-ods Thirty healthy individuals(control group), and 30 T2DM patients with CAD(T2DM+CAD) group were select-ed.ELISA was used for determination of TNF-α,IL-1βand OPG,biochemistry method for blood glucose and glycosy-lated hemoglobin , and the data in all groups and the relationship between the factors was observed .Results Fasting blood-glucose, glycosylated hemoglobin, OPG in T2DM group were obviously higher than those in control group (P<0.01),and TNF-α,IL-1βin T2DM group were obviously higher than those in control group (P<0.05).Spearman correlation analysis showed that the positive correlation existed between OPG and TNF-α,IL-1β(P<0.01).Conclu-sion The levels of blood glucose ,glycosylated hemoglobin ,TNF-α,IL-1βand OPG in T2MD group increase obvious-ly.The level of OPG was related to the changes of TNF-αand IL-1β.
Keywords：Type 2 Diabetes mellitus(T2DM)Coronary artery diseaseTumor necrosis factor-αIn-terleukin-1βOsteoprotegerin
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 106-108 )