Changes and clinical significance of T lymphocyte subsets and regulatory T cells in peripheral blood of pa- tients with steroid-resistant nephrotic syndrome
Abstract：Objective To investigate the change trend of T lymphocyte subsets ( CD3 +CD4 +,CD3 +CD8 +, CD4/CD8) and regulatory T cells(Treg,CD4 +CD25 +highCD127low) in adult patients with steroid-resistant nephrotic syndrome(SRNS) and its clinical significance.Methods Twenty-four SRNS patients enrolled in SRNS group were chosen from 65 inpatients with primary nephrotic syndrome (PNS) first treated with prednisone (1 mg· kg-1 · d-1 ) for eight weeks , according to the state of clinical remission of PNS .Thirty normal persons were served as healthy con-trol group.T lymphocyte subsets and Treg were detected by flow cytometry before treatment (W0 group), after 4-week treatment(W4 group) and after 8-week treatment(W8 group).Results ①Compared with W0 group, plasma albu-min( Alb) increased significantly ( P<0.05 ) , while urinary protein , serum creatinine ( Scr ) , blood urea nitrogen (BUN), cholesterol(Cho)and triglycerides(TG) had no significant differences in W8 group(P>0.05).②Com-pared with control group , CD4%and CD4/CD8 ratio increased significantly , while Treg/CD4 ratio decreased signifi-cantly in W0 group(P<0.05).Compared with W0 group,CD4%,CD8%,CD4/CD8,Treg and Treg/CD4 had no sig-nificant differences in W8 group(P>0.05).Conclusion There are changes of T cell populations , T lymphocyte subsets and Treg/CD4 ratio imbalance in SRNS adult patients .The clinical manifestation and the disorder immune state even sustained after 8-week treatment of glucocorticoid .
Keywords：Nephritic syndromeRegulatory T lymphocytes ( Treg)T lymphocyte subsetsImmuneGlucocorticoid
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 99-103 )