Research of the relationship between expression of BRCA1 and prognosis in nasopha ryngeal cancinoma

doi:10.3969/j.issn.1674-3806.2014.02.01

Abstract：Objective To investigate the protein expression of Breast cancer 1(BRCA1) in nasopharyngeal carcinoma(NPC) and to analyze the relationship of BRCA1 expression with the prognosis.Methods The expression of BRCA1 proteins in the tissue of nasopharyngeal carcinoma in 100 patients with NPC was detected by immunohisto-chemistry.The high BRCA1 expression group included patients whose biopsy specimens showed at least 50%immu-nopositive tumor cells;The low BRCA1 expression group included patients whose biopsy specimens showed less than 50% immunopositive tumor cells , including negative expression .The correlations between protein expression and clin-ical data were assessed using the chi-square test.Results Thirteen patients failed to be followed-up.And in the rest 87 patients, the high BRCA1 expression group and low BRCA 1 expression group included 37 patients(42.5%) and 50 patients(57.5%) respectively.No significant differences were found between the expression of BRCA 1 proteins and TNM stage(P=0.383), tumor regression(P=0.434), or distant metastasis(P=0.055).The survival rate in the high BRCA1 expression group was higher than that in the low BRCA 1 expression group , but there was no statisti-cally significant differences between two groups ( P>0.05 ) .Conclusion There was no significant correlation be-tween the expression level of BRCA 1 and TNM stage and tumor regression in nasopharyngeal carcinoma .However ,the low expression of BRCA 1 were more prone to metastasis tendency .